{"id":62866,"date":"2026-05-19T06:28:22","date_gmt":"2026-05-19T05:28:22","guid":{"rendered":"https:\/\/www.filtrox.com\/?p=62866"},"modified":"2026-05-19T06:55:10","modified_gmt":"2026-05-19T05:55:10","slug":"filtration-von-aav","status":"publish","type":"post","link":"https:\/\/www.filtrox.com\/ch\/blog\/2026\/05\/19\/filtration-von-aav\/","title":{"rendered":"Filtration von AAV"},"content":{"rendered":"\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile\" style=\"grid-template-columns:40% auto\"><figure class=\"wp-block-media-text__media\"><img decoding=\"async\" width=\"595\" height=\"1024\" data-src=\"https:\/\/www.filtrox.com\/wp-content\/uploads\/2026\/05\/AAV-Downstream-Processing-Puradisc-SU-web-595x1024.jpg\" alt=\"AAV downstream processing. \" class=\"wp-image-62859 size-full lazyload\" data-srcset=\"https:\/\/www.filtrox.com\/wp-content\/uploads\/2026\/05\/AAV-Downstream-Processing-Puradisc-SU-web-595x1024.jpg 595w, https:\/\/www.filtrox.com\/wp-content\/uploads\/2026\/05\/AAV-Downstream-Processing-Puradisc-SU-web-174x300.jpg 174w, https:\/\/www.filtrox.com\/wp-content\/uploads\/2026\/05\/AAV-Downstream-Processing-Puradisc-SU-web-768x1322.jpg 768w, https:\/\/www.filtrox.com\/wp-content\/uploads\/2026\/05\/AAV-Downstream-Processing-Puradisc-SU-web-14x24.jpg 14w, https:\/\/www.filtrox.com\/wp-content\/uploads\/2026\/05\/AAV-Downstream-Processing-Puradisc-SU-web-21x36.jpg 21w, https:\/\/www.filtrox.com\/wp-content\/uploads\/2026\/05\/AAV-Downstream-Processing-Puradisc-SU-web-28x48.jpg 28w, https:\/\/www.filtrox.com\/wp-content\/uploads\/2026\/05\/AAV-Downstream-Processing-Puradisc-SU-web.jpg 800w\" data-sizes=\"(max-width: 595px) 100vw, 595px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 595px; --smush-placeholder-aspect-ratio: 595\/1024;\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p><strong>AAV-Downstream-Processing ist kein Filtrationsproblem \u2013 es ist ein Problem des Variabilit\u00e4tsmanagements<\/strong><\/p>\n\n\n\n<p>Zusammensetzungsschwankungen des Feeds, Feststoffvariabilit\u00e4t und Schersensitivit\u00e4t bestimmen die Prozessstabilit\u00e4t, nicht nominale Filterratings. In diesem Kontext ist Filtration keine passive Prozesskomponente mehr. Die Filtration selbst wird Teil der Prozessdynamik. <br \/>Starre Filtrationsaufbauten neigen dazu, Schwankungen direkt weiterzugeben: Kleine Ver\u00e4nderungen im Feed k\u00f6nnen unmittelbare \u0394p-Reaktionen (Differenzdruckreaktionen) und instabiles Flie\u00dfverhalten verursachen. \u0394p ist nicht nur ein Druckwert \u2013 er ist ein Echtzeit-Indikator daf\u00fcr, wie das System auf Prozessvariabilit\u00e4t reagiert. <br \/>Nachgiebigere bzw. flexiblere Systemarchitekturen verhalten sich anders: Sie d\u00e4mpfen Druckschwankungen, gl\u00e4tten das Str\u00f6mungsprofil und reduzieren die Ausbreitung von Prozessrauschen. Genau hier wird das Systemdesign entscheidend.<\/p>\n<p>Ein flexibles Single-Use-Setup wie <strong>PURADISC SU<\/strong> bringt eine inh\u00e4rente hydraulische D\u00e4mpfung mit sich, stabilisiert den \u0394p-Verlauf und reduziert die durch das System verursachte Variabilit\u00e4t im Prozess.<\/p>\n\n\n\n<p>F\u00fcr AAV-Prozesse bedeutet dies:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Schutz schersensitiver Vektoren<\/li>\n\n\n\n<li>verbesserte Prozesskonsistenz<\/li>\n\n\n\n<li>besser vorhersagbares Scale-up-Verhalten<\/li>\n<\/ul>\n\n\n\n<p>In der AAV-Produktion ist Stabilit\u00e4t kein Luxus\u00a0 sie ist ein entscheidender Faktor f\u00fcr den Ertrag. AAV-Filtration optimiert man nicht durch einen Filterwechsel \u2013 man optimiert sie durch die Kontrolle der Systemreaktion.<\/p>\n<p>\u00a0<\/p>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"AAV-Downstream-Processing ist kein Filtrationsproblem \u2013 es ist ein Problem des Variabilit\u00e4tsmanagements Zusammensetzungsschwankungen des Feeds, Feststoffvariabilit\u00e4t und Schersensitivit\u00e4t bestimmen die Prozessstabilit\u00e4t, nicht nominale Filterratings. In diesem Kontext ist Filtration keine passive Prozesskomponente mehr. Die Filtration selbst wird Teil der Prozessdynamik. Starre Filtrationsaufbauten neigen dazu, Schwankungen direkt weiterzugeben: Kleine Ver\u00e4nderungen im Feed k\u00f6nnen unmittelbare \u0394p-Reaktionen (Differenzdruckreaktionen) und &hellip; <a href=\"https:\/\/www.filtrox.com\/ch\/blog\/2026\/05\/19\/filtration-von-aav\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Filtration von AAV<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a>","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[470,509,38],"tags":[],"class_list":["post-62866","post","type-post","status-publish","format-standard","hentry","category-news-life-science-ch","category-news-life-science-ch-2","category-uncategorized-ch"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Filtration von AAV - Filtrox<\/title>\n<meta name=\"description\" content=\"Filtration von AAV. 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