Optimized solutions for Plasmid- DNA clarification and purification

PURADISC® BIO SD is the state-of-the-art technology for alluvial filtration for Plasmid-DNA clarification. It is based on depth filters that capture contaminants in their three-dimensional matrix. The used PURAFIX® depth filters are low in extractable ions and pyrogens. By adding filter aid, such as diatomaceous earth, the capacity per m² filter area can be drastically increased. 

Save one process step
The main advantage of alluvial filtration for the clarification step of Plasmid-DNA is the elimination of the two-step approach. Due to the increased filtration capacity the traditional approaches such as centrifugation followed by depth filtration or a two-step depth filtration are not necessary anymore. The simultaneous reduction of impurities e.g. HCP is another advantage.