Category Archives: News Life Science

Results of Life Science News

Find out more on the Life Science applications page

 

Grand Opening Ceremony in Mexico

News, News Food & Beverage, News Frying Oil, News Life Science, Uncategorized

Last week marked again a milestone in FILTROX history as we unveiled our new production line at our facility in Tlalnepantla, Mexico! It was an honor to host guests from the U.S., Mexico, Peru, Colombia, Guatemala, the Dominican Republic, and Brazil, including esteemed officials, suppliers, partners, and distributors. His Excellency Piero Piffaretti, the Swiss Ambassador to Mexico, joined José Maria Padilla of the State of Mexico and Carmen Ugalde of Tlalnepantla City for the ribbon-cutting ceremony.

A huge thank you to the organizing committee for their stellar preparation, and to the entire FILTROX Team in Mexico for their outstanding hospitality! This achievement is a testament to the power of teamwork. 

Scale-up Test Kit

News Life Science, Uncategorized

Finding the right depth filter is not easy and often time-consuming. The FILTROX Scale-up Test Kit supports you in finding the best depth filter solution for your application in a simple and efficient way, whether depth filtration or alluvial filtration.

With the included material, you can start with 20 mL experiments and scale-up the results to your desired batch size.

Application Note: Clarification of 3 Herb Extract

News Life Science

This application note is about the clarification of a 3 herb extract for cosmetic products using depth filtration. In collaboration with WELEDA in Arlesheim, Switzerland

TAKEOVER OF SCHMID AUTOMATION – Management Buy-Out

News, News Food & Beverage, News Life Science, Uncategorized

Simon Sauter completes management buy-out

We are pleased to inform you that the management buy-out process of Schmid Automation AG, which has started five years ago, has now been completed.  Simon Sauter takes over the entire business of Schmid Automation AG, including its subsidiaries Schmid Automation GmbH, Augsburg and Schmid Schaltanlagen AG, St. Gallen, retroactively per 1st of November 2022. Simon Sauter has been Managing Director of Schmid Automation since 2017 and already held a minority stake in the company. Until now, the remaining shares belonged to FILTROX Holding AG. In the future, FILTROX wants to focus entirely on its core business, which is depth filtration of valuable liquids. …

SCHMID AUTOMATION Media Release November 10th 2022Download

Application Note: Clarification of a mAb-producing cell culture.

News, News Life Science

In this Application Note, the optimization of the filtration process of a mAb-contained CHO cell culture is shown in detail. So far, the suspension is filtered in three steps, before a sterile filtration using a 0.2 μm membrane is applicable. To ensure the sterile filtration step, a flocculant has to be added prior to each filtration. In order to reduce the number of process steps in the cell harvest process, filtration tests with FILTROX depth filter sheets are performed in the laboratory scale.

The aim is to determine the most suitable filter aid and its ideal quantity and, in addition, to achieve turbidity values below 30 NTU to ensure subsequent sterile filtration. 

READ THE APPLICATION NOTE

filter cake produced in a 2" capsule during filtration tests

CBD Oil Clarification and Purification

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About CBD Oil clarification and purification
Raw hemp extracts contain high concentrations of cannabinoids but will also contain contaminants and impurities like plant particles, chlorophyll and debris as well as unwanted oils and waxes. Discover our optimized 2-step filtration and purification solution to remove the unwanted contaminants and color.  

purification and clarification of CBD Oil



Read the

APPLICATION NOTE


An example of how such a filtration can be carried out. (PDF)



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WEBPAGE


Find out more details about the clarification and purification of CBD Oil and the related products.

Clarification and Purification for extracts

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About clarification and purification of natural extracts
Raw hemp extracts contain high concentrations of cannabinoids but will also contain contaminants and impurities like plant particles, chlorophyll and debris as well as unwanted oils and waxes. Discover our optimized 2-step filtration and purification solution to remove the unwanted contaminants and color.  

purification and clarification of natural extracts



Read the

APPLICATION NOTE


An example of how such a filtration can be carried out. (PDF)



Go to the

WEBPAGE


Find out more details about the clarification and purification of plant extracts and the related products.

PLASMID-DNA

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Plasmid-DNA clarification, purification header

 

Optimized solutions for Plasmid- DNA clarification and purification

PURADISC® BIO SD is the state-of-the-art technology for alluvial filtration for Plasmid-DNA clarification. It is based on depth filters that capture contaminants in their three-dimensional matrix. The used PURAFIX® depth filters are low in extractable ions and pyrogens. By adding filter aid, such as diatomaceous earth, the capacity per m2 filter area can be drastically increased. 
process of purification and clarification of plasmid DNA

 

Save one process step
The main advantage of alluvial filtration for the clarification step of Plasmid-DNA is the elimination of the two-step approach. Due to the increased filtration capacity the traditional approaches such as centrifugation followed by depth filtration or a two-step depth filtration are not necessary anymore. The simultaneous reduction of impurities e.g. HCP is another advantage.

 

Find out more on our PURADISC® BIO SD webpage or contact our filtration experts:

more information about plasmid DNA clarification
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Mammalian Cells and mAb’s clarification solutions

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mab clarification

Single-use and traditional approach of clarification

The ongoing optimization of mammalian cell lines and fermentation processes leads to higher cell densities/titers and higher monoclonal antibody (mAb) yields. Due to this optimization also the biomass increases, including cell debris and other impurities, which challenges the clarification/harvest step.

The typical clarification process for mammalian cells and mAb involves a primary and a secondary clarification step. Due to potentially high shear forces and the necessity of this step to remove submicron particles, depth filtration is a mandatory step before transferring the liquid into the downstream. 

The process combines low running costs with operating robustness. 

 

Find out more on our webpage or contact our filtration experts:

more information
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LINKS AND DOWNLOADS:

LEAFLET MAMMALIAN CELLS AND MAb CLARIFICATION 

MORE ABOUT THE CLARIFICATION SOLUTIONS FOR MAMMALIAN CELLS AND MAb’s

CLARIFICATION FOR VACCINES

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clarification solutions for vaccines

Clarification for vaccines – the economic and efficient removal of cell debris and negatively charged molecules with FILTRODISC™ BIO SD and FILTRODISC™ R2U depth filter modules.

The purification of vaccines is a critical step during their complex production process. Cells and cell debris, as well as unwanted contaminants such as host cell proteins (HCPs) and nucleic acids need to be removed, while ensuring an optimal product yield. FILTROX offers a variety of filtration solutions to meet the specific needs for vaccine clarification.

A well-established and efficient technology is alluvial (or body feed) filtration with filter aids such as diatomaceous earth. Lenticular filter modules (FILTRODISC™) can be easily applied to combine the exceptional filtration capacity of filter aids with the advantages of using an enclosed filter housing (DISCSTAR™).

To further optimize pharmaceutical processes, the single use filter modules FILTRODISC™ BIO SD for alluvial filtration and FILTRODISC™ R2U (Ready2Use) for standard depth filtration of less turbid fluids are the best solution for eliminating cross-contamination risks and reducing cleaning validation efforts. This technology is easy to implement and linear scalable from lab to production. 

Linear scale up
from lab to production.

Reduction of costs and production steps
by saving the centrifuge step.

Single-use solution 
eliminates cross-contamination risks and reduces cleaning validation efforts.

SPECIFIC IMPURITIES TO REMOVE?

To address the removal of specific impurities, filter sheets containing adsorbants with functional properties such as cationic resins (PURAFIX® CH ZP) and activated carbon (CARBOFIL™) are used. 

 

Find out more on our webpage or contact our filtration experts:

more information
Contact button

 

LINKS AND DOWNLOADS:

VIDEO FILTRODISC BIO SD 

ABOUT ALLUVIAL FILTRATION (PDF download)

BROCHURE CARBOFIL™ (PDF download)

VIDEO CARBOFIL™ WITH ACTIVATED CARBON

GO TO THE TECHNICAL DATA SHEETS

Alluvial Filtration

News, News Life Science, ,

An Economical Solution for Midstream Clarification

Introduction
Continuous process optimization is a key factor in the biotech industry. With higher particle loads (>108 cells/ml), standard technologies for cell removal (midstream processing) – e.g. centrifugation, separation, membrane- and depth filtration – find their limits.


To increase efficiency and making the midstream process more economical alluvial filtration is the state-of-the-art solution. Alluvial filtration is a type of depth filtration and a well-established, econo-mical method in pharmaceutical industries (e.g. plasma fractionation). Instead of using an immobilized depth filter medium, filter aid (e.g. diatomaceous earth, perlite) is used to constantly build a filter cake during filtration. The filter cake with its resistance acts then as the actual filter medium. Alluvial filtration, therefore, leads to a higher filter capacity – especially with compressible particles, e.g. microbial or mammalian cells. This technology leads to a maximum product yield and highest economic efficiency and is linear scalable from lab to production scale.

Read more (PDF)

Filtration process

CBD products: the filtration

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Depth filtration solutions for CBD oils, hemp oils and extracts, cannabis oil

Producing pure and safe CBD products is the goal of every quality-conscious manufacturer of cannabis products. Raw hemp extracts contain high concentrations of cannabinoids, but will also contain contaminants and impurities like plant particles, chlorophyll and debris as well as unwanted oils and waxes. Why certain contaminants should be removed:

Chlorophyll:
• bitter taste and highly unstable
• will cause degradation of cannabinoids

 Waxes:
• very sticky components
• removal leads to smoother texture and consistency

Filtration and purification steps of CBD products and oils

In order to ensure product quality and safety, filtration is essential. To remove the waxes, fats and oil from the winterization a multi-step filtration is recommended. Depending on the batch size different approaches are possible. Find out more about the filtration steps. more…

Would you like to get to know us personally and find out more about our depth filtration solutions? Visit us at MJBizCon in Las Vegas, Dec 11-13, 2019 / Stand C9238.  MJBizCon, is the largest gathering of cannabis business professionals in the world. With 35,000 attendees and programming to benefit every sector, there is no place like it to equip your business for growth. We look forward to meeting you there. more about MJBizCon