Tag Archives: single-use filtration

Mammalian Cells and mAb’s clarification solutions

mab clarification

Single-use and traditional approach of clarification

The ongoing optimization of mammalian cell lines and fermentation processes leads to higher cell densities/titers and higher monoclonal antibody (mAb) yields. Due to this optimization also the biomass increases, including cell debris and other impurities, which challenges the clarification/harvest step.

The typical clarification process for mammalian cells and mAb involves a primary and a secondary clarification step. Due to potentially high shear forces and the necessity of this step to remove submicron particles, depth filtration is a mandatory step before transferring the liquid into the downstream. 


The process combines low running costs with operating robustness. 


 

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LEAFLET MAMMALIAN CELLS AND MAb CLARIFICATION 

MORE ABOUT THE CLARIFICATION SOLUTIONS FOR MAMMALIAN CELLS AND MAb’s