From laboratory to production scale. How to find the optimal solution for your filtration process. From laboratory trials to estimate the perfect filter sheet to calculation for your individual production scale. Read the application note: https://bit.ly/2XS4leh
An Economical Solution for Midstream Clarification
Introduction Continuous process optimization is a key factor in the biotech industry. With higher particle loads (>108 cells/ml), standard technologies for cell removal (midstream processing) – e.g. centrifugation, separation, membrane- and depth filtration – find their limits.
To increase efficiency and making the midstream process more economical alluvial filtration is the state-of-the-art solution. Alluvial filtration is a type of depth filtration and a well-established, econo-mical method in pharmaceutical industries (e.g. plasma fractionation). Instead of using an immobilized depth filter medium, filter aid (e.g. diatomaceous earth, perlite) is used to constantly build a filter cake during filtration. The filter cake with its resistance acts then as the actual filter medium. Alluvial filtration, therefore, leads to a higher filter capacity – especially with compressible particles, e.g. microbial or mammalian cells. This technology leads to a maximum product yield and highest economic efficiency and is linear scalable from lab to production scale.